Multidisciplinary Care of the Head and Neck Cancer Patient by Ellie Maghami & Allen S. Ho

Author:Ellie Maghami & Allen S. Ho
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

9.5 Fractionation Patterns

Radiation treatment is typically administered daily for approximately 7 weeks. However, a variety of alternative schedules can be employed, including 6 treatments per week [14], twice a day treatment [15], or daily treatment for the first 18 days followed by twice daily treatment for the remaining 12 days [15], to name a few. These altered fractionation regimens are most commonly used when patients are not receiving concomitant chemotherapy [16, 17]. Altered fractionated regimens can have different purposes. Hyperfractionated treatment, typically referring to twice daily treatment, aim to minimize the individual fraction size in order to either dose-escalate or minimize late effects, which are known to depend on fraction size for late-responding tissues. Accelerated fractionation refers to given the same dose and fractionation over a short period of time (e.g., 6 fractions per week) in order to minimize the effect of accelerated repopulation. Hypofractionated regimens were given in a small number of large radiation fractions, and are typically used in the palliative setting.

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